• The participant provides written informed consent

• ≥ 18 years of age on day of signing informed consent.

• Participant with histologically or cytologically confirmed diagnosis of advanced unresectable and/or metastatic solid tumors

• A male participant must agree to use contraception and refrain from sperm donation or expecting to father a child

• A female participant is eligible to participate if she is not pregnant, not breastfeeding, not a woman of childbearing potential

• Have measurable disease per RECIST 1.1 as assessed by the local site investigator/radiology

• Able to provide tumor tissue sample.

• Willing to undergo fresh tumor biopsy at Screening and On-treatment if archival tissue not available

• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

⁃ Life expectancy greater than or equal to 12 weeks as judged by the Investigator.

⁃ Have adequate organ function